A newly published study in Nature Communications provides important new insights into the biological mechanisms underlying paediatric Long COVID.
The publication, “Immune-metabolic trajectories delineate subgroups in paediatric long COVID”, followed children and adolescents over time using deep immune profiling, metabolomics, and longitudinal clinical assessments. The findings suggest that paediatric Long COVID may consist of biologically distinct subgroups with different immune and metabolic signatures.
Importantly, serum neurofilament light chain (sNfL) measurements contributed to the classification of disease trajectories, supporting the value of neuroaxonal injury biomarkers in understanding post-viral neurological involvement in children.
Jens Kuhle contributed to this international collaboration together with partners from Germany and Switzerland.
The study further highlights the importance of interdisciplinary and translational research approaches to better characterize complex inflammatory and neurological conditions and to support future precision medicine strategies.
Read the full publication:
Immune-metabolic trajectories delineate subgroups in paediatric long COVID | Nature Communications
