Neurofilament release after axonal damage and detection of cleavage products in the blood.
The latest publication from the RC2NB team published in Nature Reviews Neurology. Neurofilament proteins have emerged as valid biomarkers of neuronal injury and loss. Based on our previous review from 2018 that summarized what was known at the time about neurofilaments as biomarkers for neurological disorders, we here provide an update on the structure and function of neurofilaments, analytical approaches, and challenges in different clinical contexts. This review focuses on the progress made in recent years towards the clinical application of neurofilaments as a biomarker in various neurological disorders.
