March 6, 2024

B cell depletion with anti-CD20 promotes neuroprotection in a BAFF-dependent manner in mice and humans

Anti-CD20 treatment does not affect TLT formation in the brains of SJL/J adoptive transfer EAE mice.

Researchers from the University of Basel and the University of Toronto, Mainz have identified a potential new mechanism by which B cell therapy may protect the brain in MS patients. This study, published in Science Translational Medicine, suggests B cell depletion may safeguard brain tissue beyond its known effect of reducing acute inflammation.   

Check out this work published by the Pröbstel lab; Tradite Neziraj, Elisabeth Pößnecker and Anne-Katrin Pröbstel.

Congratulations to all the contributors for this excellent work!

Read full article here: https://www.science.org/doi/10.1126/scitranslmed.adi0295 

© RC2NB 2025
crossmenuchevron-down